• Tello-Flores VA, Valladares-Salgadob A, Ramírez-Vargas MA, Cruz M, del-Moral-Hernándeza O, Cahua-Pablo JA, Ramírez-Ruano M, Hernández-Sotelo D, Armenta-Solis A, Flores-Alfaro E. Altered levels of MALAT1 and H19 derived from serum or serum exosomes associated with type-2 diabetes. Noncoding RNA Res. 2020: en prensa.
• Salmerón-Bárcenas EG, Illades-Aguiar B, Del Moral-Hernández O, Ortega-Soto A, Hernández-Sotelo D. HOTAIR Knockdown Decreased the Activity Wnt/β-Catenin Signaling Pathway and Increased the mRNA Levels of Its Negative Regulators in Hela Cells. Cell Physiol Biochem. 2019;53(6):948-960. https://doi.org/10.33594/000000188
• Del Moral-Hernández O, Castañón-Sánchez CA, Reyes-Navarrete S, Martínez-Carrillo DN, Betancourt-Linares R, Jiménez-Wences H, de la Peña S, Román-Román A, Hernández-Sotelo D, Fernández-Tilapa G. Multiple infections by EBV, HCMV and Helicobacter pylori are highly frequent in patients with chronic gastritis and gastric cancer from Southwest Mexico: An observational study. Medicine (Baltimore). 2019;98(3):e14124. https://doi.org/10.1097/MD.0000000000014124
• Torres-Rojas I, Alarcón-Romero LC, Leyva-Vázquez MA, Ortiz-Ortiz J, Mendoza-Catalán MA, Hernández-Sotelo D, Del Moral-Hernández O, Rodríguez-Ruiz HA, Leyva-Illades D, Flores-Alfaro E, Illades-Aguiar B. Methylation of the L1 gene and integration of human papillomavirus 16 and 18 in cervical carcinoma and premalignant lesions. Oncol Lett. 2018;15(2):2278-2286. https://doi.org/10.3892/ol.2017.7596
• Peralta-Arrieta I, Hernández-Sotelo D, Castro-Coronel Y, Leyva-Vázquez MA, Illades-Aguiar B. DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation. Am J Cancer Res 2017; 7(1): 77-87. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5250682/
• Jiménez-Wences H, Martínez-Carrillo DN, Peralta-Zaragoza O, Campos-Viguri GE, Hernández-Sotelo D, Jiménez-López MA, Muñoz-Camacho JG, Garzón-Barrientos VH, Illades-Aguiar B, Fernández-Tilapa G. Methylation and expression of miRNAs in precancerous lesions and cervical cáncer with HPV16 infection. Oncol Rep. 2016;35(4):2297-305. https://doi.org/10.3892/or.2016.4583
• Hernández-Sotelo D, Ortiz-Ortiz J, Alarcón-Romero LC, Peralta-Arrieta I, Castro-Coronel Y, Del Moral-Hernández O, Leyva-Vázquez MA, Illades-Aguiar B. HPV in men and concordance of viral types in infected couples in southern Mexico. Int J Clin Exp Pathol 2016;9(2):2106-2112. ISSN:1936-2625.
• Campos-Viguri G, Jiménez-Wences H, Peralta-Zaragoza O, Torres-Altamirano G, Soto-Flores D, Hernández-Sotelo D, Alarcón Romero LC, Jiménez-López MA, Illades-Aguiar B, Fernandez-Tilapa G. miR-23 as a potential tumor suppressor and its regulation by DNA methylation in cervical cancer. Infect Agent Cancer. 2015;10:42. https://doi.org/110.1186/s13027-015-0037-6
• Cahua-Pablo G, Cruz M, Del Moral-Hernández O, Leyva-Vázquez MA, Antúnez-Ortiz DL, Cahua-Pablo JA, Alarcón-Romero LC, Ortuño-Pineda C, Moreno-Godínez ME, Hernández-Sotelo D, Flores-Alfaro E. Elevated levels of LDLc are associated with ApoE4 but not with the rs688 polymorphism in the LDLR gene. Clin Appl Thromb Hemost. 2016;22(5):465-70. https://doi.org/10.1177/1076029614568714
• Antonio-Véjar V, del Moral-Hernández O, Alarcón-Romero LC, Flores-Alfaro E, Leyva-Vázquez MA, Hernández-Sotelo D, Illades-Aguiar B. Ethnic variation of C677T and A1298C polymorphisms in the methylenetetrahydrofolate-reductase (MTHFR) gene in southwestern Mexico. Genet Mol Res; 2014; 13(3): 7950-7. https://doi.org/10.4238/2014.September.29.8
• Del Moral-Hernández O, Martínez-Hernández NE, Mosso-Pani MA, Hernández-Sotelo D, Illades-Aguiar B, Flores-Alfaro E, Antonio-Véjar V, Leyva-Vázquez MA. Association DENV1 and DENV2 infection with high serum levels of soluble thrombomodulin and VEGF in patients with dengue fever and dengue hemorrhagic fever. Int J Clin Exp Med. 2014; 7(2):370-378. https://europepmc.org/articles/pmc3931590
• Jiménez-Tagle DK, Hernández-Sotelo D, Illades-Aguiar B, Leyva-Vázquez MA, Flores-Alfaro E, Castro-Coronel Y, del Moral-Hernández O, Alarcón-Romero LC. Expression of E6, p53 and p21 proteins and physical state of HPV16 in cervical cytologies with and without low grade lesions. Int J Clin Exp Med. 2014;7(1):186-193. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902258/
• Hernández- Sotelo D, García-Aguilar, R, Castro-Coronel, Y, J Magaña J, Leyva-Vázquez MA, Alarcón-Romero LC, López Bayghen, E, Illades-Aguiar, B. The 46359CT polymorphism of DNMT3B is associated with the risk of cervical cáncer. Mol Biol Rep. 2013;40:4275-4280. https://doi.org/10.1007/s11033-013-2511-9
• Illades-Aguiar B, Cortés-Malagón EM, Antonio-Véjar V, Zamudio-López N, Alarcón-Romero L del C, Fernández-Tilapa G, et al. Cervical carcinoma in Southern Mexico: Human papillomavirus and cofactors. Cancer Detect Prev. 2009;32(4):300-7. https://doi.org/10.1016/j.cdp.2008.09.001

Proyectos de Investigación

Responsable

• Análisis e identificación de los elementos que determinan la metilación de los genes blanco de DNMT3B: análisis a escala global. CONACYT Ciencia Básica 2014.
• Efecto de la metilación del LCR del VPH 16 y 18 en la actividad transcripcional de E6 y E7. UAGRO 2013.

Participante

• Efecto de la metformina sobre el perfil de expresión de lncRNAs circulantes en vesículas extracelulares en un modelo in vitro de resistencia a la insulina. Financiado por el CONACYT, Fondo Ciencia Básica. Clave: 283801. 2018-2021.
• Diseño de un panel de biomarcadores para la detección temprana de cáncer cérvico uterino a partir de una sola toma de muestra. Fondo Sectorial de Investigación en Salud y Seguridad Social-CONACyT. 2014-2016.