• Juárez-Cruz JC, Zuñiga-Eulogio MD, Olea-Flores M, Castañeda-Saucedo E, Mendoza-Catalán MA, Ortuño-Pineda C, Moreno-Godinez ME, Villegas-Comonfort S, Padilla-Benavides T, Navarro-Tito N. Leptin induces cell migration and invasion in a FAK-Src- dependent manner in breast cancer cells. Endocr Connect. 2019. pii: EC-19-0442. https://doi.org/10.1530/EC-19-0442
• Isaías-Tizapa R, Acosta E, Tacuba-Saavedra A, Mendoza-Catalán M, Navarro-Tito N. The Leptin induced Hic-5 expression and actin puncta formation by the FAK/Src-dependent pathway in MCF10A mammary epithelial cells. Biomedica. 2019;39(3):547-560. https://doi.org/10.7705/biomedica
• Arreguin-Cano JA, Ayerdi-Nájera B, Tacuba-Saavedra A, Navarro-Tito N, Dávalos-Martínez A, Emigdio-Vargas A, Barrera-Rodríguez E, Blanco-García N, Gutiérrez-Venegas G, Ventura-Molina E, León-Dorantes G. MMP-2 salivary activity in type 2 diabetes mellitus patients. Diabetol Metab Syndr. 2019;11:113. https://doi.org/10.1186/s13098-019-0510-2
• Olea-Flores M, Zuñiga-Eulogio M, Tacuba-Saavedra A, Bueno-Salgado M, Sánchez-Carvajal A, Vargas-Santiago Y, Mendoza-Catalán MA, Pérez Salazar E, García-Hernández A, Padilla-Benavides T, Navarro-Tito N. Leptin Promotes Expression of EMT-Related Transcription Factors and Invasion in a Src and FAK-Dependent Pathway in MCF10A Mammary Epithelial Cells. Cells. 2019;8(10). pii: E1133. https://doi.org/10.3390/cells8101133
• Olea-Flores M, Zuñiga-Eulogio MD, Mendoza-Catalán MA, Rodríguez-Ruiz HA, Castañeda-Saucedo E, Ortuño-Pineda C, Padilla-Benavides T, Navarro-Tito N. Extracellular-Signal Regulated Kinase: A Central Molecule Driving Epithelial-Mesenchymal Transition in Cancer. Int J Mol Sci. 2019;20(12). pii: E2885. https://doi.org/10.3390/ijms20122885
• Gordon SJV, Xiao Y, Paskavitz AL, Navarro-Tito N, Navea JG, Padilla-Benavides T. Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells. J Vis Exp. 2019;(147). https://doi.org/10.3791/59519
• Olea-Flores M, Juárez-Cruz JC, Mendoza-Catalán MA, Padilla-Benavides T, Navarro-Tito N. Signaling Pathways Induced by Leptin during Epithelial⁻Mesenchymal Transition in Breast Cancer. Int J Mol Sci. 2018 Nov 6;19(11). pii: E3493. https://doi.org/10.3390/ijms19113493
• Juan Carlos Juárez Cruz, Adriana Soto Guzmán, Angélica Martínez López, Napoleón Navarro Tito. (2019). Obesidad y cáncer de mama: una relación entre epidemias modernas. Biotecnia. In press.
• Yarely M Salina-Vera, Laurence A Marchat, Raúl García-Vázquez, Claudia H González de la Rosa, Eduardo Castañeda-Saucedo, Napoleon Navarro-Tito, Carlos Palma-Flores, Carlos Pérez-Plasencia, Jose L Cruz-Colin, Ángeles Carlos-Reyes, Sullivan López González, María Elizbeth Álvarez Sánchez, César López-Camarillo. (2018). Cooperative multi-targeting of signaling networks by angiomiR-204 inhibits vasculogenic mimicry in breast cancer cells. Cancer Letters. 2018. 28 (432): 17-27. https://doi.org/10.1016/j.canlet.2018.06.003
• Zacapala-Gómez AE, Navarro-Tito N, Alarcón-Romero LDC, Ortuño-Pineda C, Illades-Aguiar B, Castañeda-Saucedo E, Ortiz-Ortiz J, Garibay-Cerdenares OL, Jiménez-López MA, Mendoza-Catalán MA. Ezrin and E-cadherin expression profile in cervical cytology: a prognostic marker for tumor progression in cervical cáncer. BMC Cancer. 2018. 18 (1): 349. https://doi.org/10.1186/s12885-018-4243-7
• Villanueva-Duque A, Zuniga-Eulogio D, Dena-Beltran J, Castaneda-Saucedo E, Calixto-Galvez M, Mendoza-Catalan MA, Ortuno-Pineda C, Navarro-Tito N. Leptin induces partial epithelial-mesenchymal transition in a FAK-ERK dependent pathway in MCF10A mammary non-tumorigenic cells. Int J Clin Exp Pathol. 2017. 10 (10):10334-10342. http://www.ijcep.com/files/ijcep0058411.pdf
• Serna-Marquez N, Villegas-Comonfort S, Galindo-Hernandez O, Navarro-Tito N, Millan A, Salazar EP. Role of LOXs and COX-2 on FAK activation and cell migration induced by linoleic acid in MDA-MB-231 breast cancer cells. Cell Oncol. 2013. 36 (1): 65-77. https://doi.org/10.1007/s13402-012-0114-4
• Villegas-Comonfort S, Serna-Marquez N, Galindo-Hernandez O, Navarro-Tito N, Salazar EP. Arachidonic acid induces an increase of b-1,4-galactosyltransferase I expression in MDA-MB-231 breast cancer cells. J Cell Biochem. 2012. 113 (11): 3330-41. https://doi.org/10.1002/jcb.24209
• Castro-Sanchez L, Soto-Guzman A, Navarro-Tito N, Martinez-Orozco R, Salazar EP. Native type IV collagen induces cell migration through a CD9 and DDR1-dependent pathway in MDA-MB-231 breast cancer cells. Eur J Cell Biol. 2010. 89 (11): 843-52. https://doi.org/10.1016/j.ejcb.2010.07.004
• Soto-Guzman A, Navarro-Tito N, Castro-Sanchez L, Martinez-Orozco R, Salazar EP. Oleic promotes MMP-9 secretion and invasion in breast cancer cells. Clin Exp Metastasis. 2010. 27(7):505-15. https://doi.org/10.1007/s10585-010-9340-1
• Martinez-Orozco R, Navarro-Tito N, Soto-Guzman A, Castro-Sanchez L, Perez Salazar E. Arachidonic acid promotes epithelial-to-mesenchymal like transition in mammary epithelial cells MCF10A. Eur J Cell Biol. 2010. 89 (6): 476-88. https://doi.org/10.1016/j.ejcb.2009.12.005
• Navarro-Tito N, Soto-Guzman A, Castro-Sanchez L, Martinez-Orozco R, Salazar EP. Oleic acid promotes migration on MDA-MB-231 breast cancer cells through an arachidonic acid-dependent pathway. Int J Biochem Cell Biol. 2010. 42 (2): 306-17. https://doi.org/10.1016/j.biocel.2009.11.010
• Navarro-Tito N, Robledo T, Salazar EP. Arachidonic acid promotes FAK activation and migration in MDA-MB-231 breast cancer cells. Exp Cell Res. 2008. 314 (18): 3340-55. https://doi.org/10.1016/j.yexcr.2008.08.018

Proyectos de Investigación 

Responsable

• Estudio de la transición epitelio-mesenquimal inducida por leptina en células epiteliales mamarias: papel de las cinasas FAK y Src. Financiado por CONACYT, Ciencia Básica. Clave: 239870. 2015-2018.
• Papel de las cinasas FAK/Src sobre la secreción de metaloproteinasas de matriz e invasión en células de cáncer de mama estimuladas con leptina. Financiado por PROMEP: Apoyo a la Incorporación de Nuevos PTC. Diciembre 2014-Noviembre 2015.